Serum levels of progesterone and estradiol in menopausal women and users of hormonal contraceptives undergoing dental treatment


Objectives: to assess whether women who are using hormonal contraceptives are at similar risk to menopause for oral problems related to falling levels of sexual hormones. Methods: serum estradiol and progesterone were measured to compare levels among women of childbearing age who use oral contraceptives or intrauterine devices with menopausal or hysterectomized women. The Mann-Whitney test was used to compare the plasma concentration of progesterone and estradiol between the groups and statistical significance was set at p<0.05. Results: fifty-two (52) women divided into two groups, 27 women aged 16 to 47 years, which used oral contraceptive methods or hormonal intrauterine device and 25 menopausal or hysterectomized women aged 45 to 76 years. Progesterone serum concentration (0.36 ± 0.13 ng / mL vs. 0.21 ± 0.03 ng / mL, p = 0.001) was significantly higher in the contraceptive group. The concentration of estradiol (19.8 ± 12.5 ng / mL vs. 15.2 ± 4.6 ng / mL, p = 0.263) was similar between the groups. Conclusions: women of childbearing age using hormonal contraceptives had similar estradiol levels to those of menopausal women. Low levels of this hormone may predispose to oral pathologies, so women should receive special attention at the dental care level.

Keywords: Progesterone. Estradiol. Menopause. Female contraceptives. Hormone replacement therapy

Adriana Della Giustina Perin;
Amália Cinthia Meneses Rêgo;
Fausto Pierdoná Guzen;
Irami Araújo-Filho;
Ricardo Ney Cobucci

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