Phytol, a Chlorophyll Component, Prevents Motor Impairments Induced by Reserpine in Rats

Abstract:
 Phytol (PHY), a constituent of chlorophyll, has some pharmacological properties such as an­tioxidant, anti-inflammatory, anxiolytic, antide­pressant, and antihyperalgesic effects. Compou­nds like this one have a high potential to develop neuroprotective action. Repeated administration of reserpine (RES) in rodents induces motor im­pairments and has been applied has been applied to Parkinson’s disease (PD) and tardive dyskinesia (TD) animal models. Therefore, the present study investigated whether phytol administra­tion would attenuate reserpine-induced motor impairments in rats. Male Wistar rats received subcutaneous injections of 1 mg/kg RES or vehicle, in two conse­cutive days, concomitantly with intra­peritoneal injections of PHY (50 mg/ kg) or vehicle. Catalepsy test was asses­sed from day 1 to day 3. On day 3, oral movements and locomotor activity were evaluated. Our results showed that PHY prevented an increase in cataleptic beha­vior, number of vacuous chewing move­ments, oral tremor, and tong protrusion. However, it was unable to prevent a re­duction in open-field locomotor activity induced by RES. Our results suggest that PHY shows a protective effect in in PD and TD animal models, preventing mo­tor impairments induced by RES.

Keywords: Neuroprotective Effect. Diterpenes. Parkinson Disease. Tardive Oral Dyskinesia.

Authors:
Wesley Santos Santana;
Edson de Rezende Santos;
Heitor Santos Franco;
Mylaine Santos Mendonça;
Thiago Henrique Almeida-Souza;
Ana Cleia A. da Luz;
José Leandro Santos Souza;
Auderlan Mendonça de Gois;
Pollyana Caldeira Leal;
Lucindo José Quintans-Júnios;
José Ronaldo dos Santos.

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