Abstract:
Phytol (PHY), a constituent of chlorophyll, has some pharmacological properties such as antioxidant, anti-inflammatory, anxiolytic, antidepressant, and antihyperalgesic effects. Compounds like this one have a high potential to develop neuroprotective action. Repeated administration of reserpine (RES) in rodents induces motor impairments and has been applied has been applied to Parkinson’s disease (PD) and tardive dyskinesia (TD) animal models. Therefore, the present study investigated whether phytol administration would attenuate reserpine-induced motor impairments in rats. Male Wistar rats received subcutaneous injections of 1 mg/kg RES or vehicle, in two consecutive days, concomitantly with intraperitoneal injections of PHY (50 mg/ kg) or vehicle. Catalepsy test was assessed from day 1 to day 3. On day 3, oral movements and locomotor activity were evaluated. Our results showed that PHY prevented an increase in cataleptic behavior, number of vacuous chewing movements, oral tremor, and tong protrusion. However, it was unable to prevent a reduction in open-field locomotor activity induced by RES. Our results suggest that PHY shows a protective effect in in PD and TD animal models, preventing motor impairments induced by RES.
Keywords: Neuroprotective Effect. Diterpenes. Parkinson Disease. Tardive Oral Dyskinesia.
Authors:
Wesley Santos Santana;
Edson de Rezende Santos;
Heitor Santos Franco;
Mylaine Santos Mendonça;
Thiago Henrique Almeida-Souza;
Ana Cleia A. da Luz;
José Leandro Santos Souza;
Auderlan Mendonça de Gois;
Pollyana Caldeira Leal;
Lucindo José Quintans-Júnios;
José Ronaldo dos Santos.