Neuroprotective profile of Piper Methysticum (Kava Kava) and its effects on the Central Nervous System: a systematic review

Introduction: Piper Methysticum is a perennial shrub, native to the Pacific Ocean with historical and cultural significance, described in the literature as a compound that has a positive action on the nervous system, has anxiolytic, sedative, analgesic, anti-inflammatory, anticonvulsant and anti- ischemic effects, having kavalactones as its main component. The aim of this work was to systematically review the effects of Piper Methysticum supplementation on neurological disorders. Materials and Methods: The research was conducted through the databases PubMed, Science Direct, Cochrane Library, Scopus, Web of Science, Medline via Proquest and Capes Periodicals, through which a quantity of 10 pertinent articles was gathered. Results: Piper Methysticum demonstrated significant positive responses to reduce oxidative stress and neuroinflammation in neurodegenerative diseases. In addition, Piper methysticum extract can have anti-ischemic and anticonvulsant effects mediated by blocking the Na+ channel voltage, as well as behavioral changes similar to anxiolytics and significant sedation. Conclusion: Thus, considering that Piper methysticum proves to be effective and has a phytotherapeutic potential to act as an adjuvant or alternative to existing drugs.

Keywords: Central nervous system (CNS); Piper Methysticum (kava-kava); Neuroprotection; Anxiety; Neurodegenerative diseases.

Elaine Cristina Gurgel Andrade Pedrosa;
Ana Paula Carvalho Bezerra;
Ianara Mendonça da Costa;
Francisco Irochima Pinheiro and
Fausto Pierdoná Guzen

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