Evaluation of the hepatic funciotn of adult men under the use of testosterone base transdermal in the municipality of Belo Horizonte – MG / Brazil

Abstract:
Introduction: Recently, an expressive interest has developed about the importance of the condition known as male climacteric or andropause. In men this process is not universal, occurring in a portion of the male population with clinical manifestations that are more gradual than those occurring in menopausal women. Objective: The present study aimed to evaluate the hepatic function of adult men under testosterone transdermal use in the city of Belo Horizonte – MG / Brazil. Methods: The subjects of the research were men, patients of the Penchel Clinic admitted in 2017. As inclusion criteria, men would need to be between 19 and 55 years of age and total testosterone measured at values below 320ng / dl, which would characterize hormone insufficiency. After 60 days of hormone use, the men underwent biochemical reassessment for analysis of testosterone values. Results: Because it is a rapid absorption, short half life and non-return liver, this route of replacement becomes an excellent alternative of choice for testosterone in 100% of the subjects (p = 0.0441), suggesting that there was no statistically significant difference between the two measures evaluate GGT, the main acute marker of hepatic lesion alteration. Conclusion: Care for testosterone-deficient patients should focus on accurate assessment of total testosterone levels, symptoms and signs, as well as appropriate monitoring during treatment to ensure that therapeutic levels of testosterone are achieved and symptoms are improved.

Keywords: Transdermal hormone replacement; Testosterone; Liver function; Andropause.

Authors:
Lucas Mendes Penchel;
Amália Cinthia Meneses do Rêgo;
Irami Araújo-Filho;
Fausto Pierdoná Guzen;
Dinalva Brito de Queiroz.

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