Cytoarchitectural Characterization of the Medial Geniculated Body of Young Wistar Rats (Rattus Norvegicus) Through Immunohistochemistry for S100B

Abstract:

Several molecular, cytoarchitectural and neurochemical works study the Medial Geniculate Body (MGB), a thalamus structure related to the auditory pathway. This region is composed of several nuclei of neurons, mainly of retransmission to the auditory cortex, in addition to astrocytes and axon fibers. In order to make MGB’s histophysiological knowledge solid, several astrocyte markers are commonly used, such as GFAP, S100B and metabolic enzyme aldehyde dehydrogenase 1 (Al- dh1L1). We studied the pattern of distribution and immunoreactivityfor S100B in the MGB of young wistar rats and we were able not only to delimit and characterize the topography as a whole of this area, but also to obtain the subdivision of some sub-regions. In this sense, we found that immunohistochemistry against S100, classically, can be used to characterize the MGB, as our results indicated that it is a reliable marker for cytoarchitectonic studies in this área in young rats.

Keywords: Astrocytes; Calcium Binding Proteins; Medial Geniculate Body; Protein S100B.

Authors:
Leandro Diniz da Silva;
Gabriel Sousa da Rocha;
Karina Maia Paiva;
Rodrigo Freire Oliveira;
Kalina Fernandes Freire;
Acydália Madruga de Mendonça Florêncio de Melo;
Ana Cristina Arrais;
Lucidio Clebeson de Oliveira;
Paulo Leonardo Araújo de Gois Morais;
Lívia Helena de Morais Freitas Melo and
José Rodolfo Lopes de Paiva Cavalcanti

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