2020

Prevalence and Associated Factors of Gestational Diabetes Mellitus

Abstract:

Objective: A cross-sectional study was carried out to estimate the prevalence of gestational diabetes mellitus (GDM) in Mossoró/RN and to evaluate the correlation of associated risk factors. Subjects and methods: Pregnant women attended at Brazilian National Health Service between January 2016 and January 2017 were evaluated using a specific questionnaire with demographics and baseline caractheristics and first trimester fasting plasma glucose glycemic (FPG), followed by OGTT 75g schedule between 24 and 28 weeks of gestation. Diagnostic criteria recommended by the IADPSG were used. Results: 166 pregnant women were recruited, with a mean age of 24.7 years, predominance of brown and white races, most with low schooling and low income, 38.5% presenting pre-gestational weight excess. Of the pregnant women with FPG collected in the first trimester, 13.8% had GDM, with a mean FPG 101.2 mg/dL; among 76 patients who completed the evaluation, 04 (5.3%) had a diagnosis of GDM with OGTT 75g, totaling 20 of 76 patients evaluated, with a total prevalence of 26.3%. Direct correlation between age and GDM was observed only in pregnant women diagnosed in the first trimester. No correlation was observed with the other factors evaluated: color, height, income, schooling, history of PCOS and gestational hypertension, family history of DM2, pre-gestational obesity and sedentary lifestyle. Conclusion: a high prevalence of GDM was identified, with a large percentage already identified in the first trimester. Additional studies are needed to better define risk factors in this population, as well as the impact of this early diagnosis on neonatal outcomes.

Keywords: Gestational diabetes. Prevalence. Risk factors.

Authors:
Gilka Firmino Torres Barisic;
Lidia Maria Oliveira Barisic;
Lucas Costa Feitosa Alves;
Stephan Barisic;
Fausto Pierdoná Guzen;
Eudes Euler de Souza Lucena.

Hyptis Suaveolens L. Poit Essential Oil Induces Trophism in Spinal Cord Cells

Abstract:
Spinal cord injury is a source of significant disabilities that needs the combination of different strategies to obtain functional recovery results. In this regard some medicinal plants also have activities in the central nervous system and their essential oils, product of the secondary metabolism, are effective in different disorders of this system. Hyptis suaveolens (L.) Poit (HS) is a plant thatproduces essential oil with antiinflammatory, antioxidant andneuroprotective activity. Thus,this study analyzed the cellularplasticity of spinal cord cells inthe presence of sciatic nerve-conditionedmedium (SNCM) and theaddition of HS essential oil. Cellmorphology was assessed over 96hours, and immunocytochemistryanalyses were conducted for Glialfibrillary acidic protein (GFAP)and Neuronal Nuclear antigen (NeuN). Photomicrographs were made by scanning electron microscopy (SEM). Morphological analysis showed evident trophic development in the groups that received HS essential oil (p<0,05), particularly glial cells, immunoreactivity for GFAP, and NeuN and the plasticity of these cells were confirmed by SEM. This study about the plasticity of spinal cord cells contributes with new possibilities and techniques with essential oils for cell therapy in the presence of SNCM, which promoted neuroprotective action.

Keywords: Spinal Cord Injuries. Neuroprotection. Neurotrophism. Essential oil.

Authors:
Luciana Cristina Borges Fernandes;
Rodrigo Freire Oliveira;
Salvador Viana Junior;
Ianara Mendonça Costa;
Francisca Idalina Neta;
Francisca Overlânia Vieira Lima;
Lucídio Clebeson Oliveira;
Sergio da Silva Bezerra de Menenzes;
Dinalva Brito de Queiroz;
Carlos Iberê Alves Freitas;
Fausto Pierdoná Guzen.

Neural Action Potential Relating to Neural Connectivity Issues on Autism Spectrum Disorder: a Mini Review

Abstract:
Autism Spectrum Disorder (ASD) is a set of neurodevelopmental features which represent limitations for the individual in his/her social, affective and functional life. Previously named as Pervasive Developmental Disorder, nowadays autism is conceived as a spectrum and is a vast fan of manifestations, usually with repetitive behavior, some delay on language acquisition and isolation. The present mini review aims to study ASD starting from the Neural Action Potential as initial element of neural networks, connectivity and relation of the individual with the environment, based on neurosciences, studies that have been published during the last 5 years on PUBMED and Google Scholar databases. Discussion takes place as a theoretical approach to possibilities of construction of those neural connections and its implications to ASD symptoms. It is urgent to spread information about ASD in order to search for better therapy strategies, relation between family and health professional formation centers as well as ameliorate ASD-assistance services.

Keywords: Autism Spectrum Disorder. Neural Action Potential. Autism Neural Connectivity.

Authors:
Amélia Carolina Lopes Fernandes;
Dayane Pessoa de Araújo;
Fausto Pierdoná Guzen;
Francisca Patrícia Barreto de Carvalho;
José Rodolfo Lopes de Paiva Cavalcanti;
Jussara Rodrigues de Alcantara;
Lisandra Alves da Silva;
Lucidio Clebeson de Oliveira;
Paulo Leonardo Araújo de Góis Morais.

Incidene of Self-Medication Amongst Elderly People

Abstract:
The work aims to know the factors that contribute to the self-medication of the elderly people, as well as to characterize the main risks of self-medication in the elder. This is an exploratory descriptive research with a quantitative approach. The study sample consisted of 144 elderly people from the municipality of Morada Nova in Ceará. Data were expressed as mean, standard deviation, minimum and maximum values, as well as simple frequency and percentage calculated using the 20.0 version of SPSS statistical software (Statistical Package for Social Sciences). It was found that 88.2% of the elderly people have had medication for more than a year, 68% have had more than three medications daily, 42.2% of the interviewees had their last appointment less than a month before, 77.8% stated that they did not have help with the use of medicines. In this sense, it was evident that the practice of self-medication is frequent in the elderly people, which reflects the need to work with health promotion groups in order to reduce possible damage caused by the inappropriate use of medicines.

Keywords: Elderly. Self-medication. Nursing.

Authors:
Thaisa Christina Reinaldo Monteiro;
Amélia Carolina Lopes Fernandes;
Dayane Pessoa de Araújo;
José Rodolfo Lopes de Paiva Cavalcanti;
Francisca Patrícia Barreto de Carvalho;
Ana Cristina Arrais;
Eudes Euler de Souza Lucena;
Lucidio Clebeson de Oliveira.

Bioactive and Nutraceutical Properties of Mushrooms in Body Aesthetic

Abstract:

Mushrooms are fruiting bodies of fungi, some species of edible mushrooms being used as part of traditional diets, such as a Mediterranean. In this sense, edible mushrooms have emerged as a viable alternative increasingly common in the Brazilian table due to their nutritional properties. This article aimed to evaluate the benefits of the bioactive and nutritional properties of mushrooms on body aesthetics. This study consists of a literature review where an electronic search was performed in the United States: PubMed, Science Direct, Cochrane Library, Scientific Electronic Library, Online Databases (SciELO), Scopus, Web of Science, Medline via Proquest and Capes Periodicals covering the years 1989-2019, using the terms “Nutrient Mushrooms” “Mushrooms, Vitamins, Food Supplementation” “Mushrooms and Nutrition and Micronutrients” “Mushrooms and Nutrition and Macronutrients”“Nutrient Mushrooms and Nutraceuticals “Mushroom and aesthetics” Mushroom and antioxidant. Mushrooms are rich in proteins with good bioavailability, low lipid content and excellent fiber source that can be used as nutritional, advanced for their bioactive compounds, polyphenols and other biological compounds that perform body aesthetic activities.

Keywords: Mushrooms. Macronutrients. Micronutrients. Body Aesthetics.

Authors:
Vinicius Umbelino de Freitas;
Anna Ingrid Soares de Sousa Espindola;
Catarina Melissa Carlos de Castro;
Fernando Liberalino Fernandes ;
Ninodja Kadja Peixoto Nóbrega;
Jenifer Kristina Alves Almeida;
Fausto Pierdoná Guzen.

Benefits of Supplementation with Herbal Medicines in Anabolic Hormone Replacement Related to Aging

Abstract:

Exercise can be carried out according to the morphological and physiological changes of the living organism over time. The increase in life expectancy is also an achievement along with functional decline and increased disease are observed. Aging in a healthy way for a general well-being, however, when aging is not successful, the elderly have a great tendency towards a functional, cognitive and other diseases, generating the total dependence of basic activities, thus determining the need care. The present article had the objective of supplementation with phytotherapics in the anabolic hormone replacement related to aging. The study was based on the literature review, and a case study was done in the United States. Library of Medicine, Pub Direct, Science Direct, Cochrane Library, Electronic Scientific Library, Online Databases (SciELO), Scopus, Web of Science, Medline via Proquest and Periodics capturing the years between 2007 and 2019, using the terms of reference “Aging and Metabolic Alterations” “Aging and Phytotherapics” “Aging and Tribulus terrestris” “Aging and Maca Peruvian” “Aging and Ginseng”, in addition we related the term hormone with each phytotherapeutic mentioned. They observe that the herbal remedies Tribulus terrestris, Maca peruana and Ginseng possess in their combination with the chemistry, anabolic, being thus, a supplementation with these products can allow an anabolic hormonal balance, generating the effect in the levels of catabolic hormones, providing a better This topic was extracted from population longevity.

Keywords: Aging. Anabolic Hormones. Herbal Medicine. Supplementation

Authors:
Anna Ingrid Soares de Sousa Espindola;
Bruna Stefany Souza Sabino;
Catarina Melissa Carlos de Castro Duarte;
Gabrielle Tereza Santos de Souza;
Marina Geovanni Marques de Santana;
Ninodja Kadja Peixoto Nóbrega;
Pedro Henrique Bezerra Gomes;
Ana Katarina Dias de Oliveira;
Fausto Pierdoná Guzen.

Serum Concentration on Mineral Zinc and Cognitive Changes in Children: a Review

Abstract:

Introduction: Micronutrient deficiencies in children in developing countries remain a public health problem, as they are persistently common. Among them, zinc is an essential trace element and plays a crucial role in biological functions and physiological processes in humans. Disorders of zinc balance during life appear to be an important factor correlated with the development of CNS diseases. This research aimed to conduct a literature review on the proportion of research involving zinc and brain development in children. Methods: A search was performed in the Pubmed, Scorpus, and Web of Science databases, and articles from the last 5 years were retrieved. According to the criteria, 7 articles were chosen to compose this review. Results: 57% revealed that children with ASD have low serum zinc levels, and 29% of the studies found lower plasma zinc levels in children diagnosed with ADHD. Revealing that attention to the levels of zinc in the plasma must be special, since mainly the levels of micronutrients, are decisive for a good biological, physiological, neurobiological, and behavioral development, acting on the personality and formation of the human being. Conclusion: In this perspective, we emphasize the importance of giving greater attention to the serum levels of adequate zinc in the human body, renewing the knowledge that adequate nutrition is of great importance for normal development from pregnancy to aging.

Keywords: Child. Zinc. Brain.

Authors:
Samillys Valeska Bezerra de França Silva;
Micheline Morgane Figueiredo Costa Souza;
Jéssica Raque de Santana;
José Edvan de Souza Júnior;
José Rodolfo Lopes de Paiva Cavalcanti.

Neurobiology of Schizophrenia: an Integrative Review

Abstract:

Psychological diseases are gaining more and more space in the medical field, being considered by some studious the evil of the century, as more and more people are affected worldwide. Among these diseases we have schizophrenia, which consists of a mental condition that modifies the perception of reality of the individual, impairing his memory and development of basic activities that require concentration and memorization. Because it develops mainly between adolescence and adulthood, without a defined cause, many studies and tests have been conducted for decades in order to o find out the precise causes of such disorders, since only with an accurate diagnosis can effective treatment be determined. From this perspective, this article aims to conduct a survey and discussion of the theoretical material already existing regarding the neurobiology of a schizophrenic in order to understand its mental disorders. Although research indicates which region of the brain, when affected, can cause disturbances there is no accuracy as to how the process occurs, it was also possible to notice little evolution in studies, and lack of accuracy of the causes of the changes neurobiologics which result in disorders.

Keywords: Psychic diseases. Neurobiology. Mental disorders.

Authors:
Ricardo dos Santos Cirilo;
Isabeline Maria de Góis Mendes Oliveira;
Fausto Pierdoná Guzen.

Clinical Applications of Nitric Oxide: Comprehensive Review

Abstract:

Around the year of 1986 nitric oxide was no longer seen by health professionals as a highly toxic molecule and began to be considered in clinical treatments. However, the discovery of their positive functions does not mitigate their negative characteristics, because of this, research and tests are performed on the functionalities and risks, however doubts and fears are still common. In biological organisms, nitric oxide may react with molecules and attenuate various processes, whereas when in contact with a high amount of the oxide or a been exposed for too long may cause intoxication. Therefore, further research and testing with the use of oxide are required to avoid com plications. Hence, the objective of the present research is to present the clinical complications caused by the use of nitric oxide in various treatments.

Keywords: Nitric Oxide. Clinical Application.

Authors:
Isabeline Maria de Góis Mendes Oliveira;
Ricardo dos Santos Cirilo;
Fausto Pierdoná Guzen.

Prevalence of anaemia in a sample of elderly northeastern brazilians

Abstract:
Population growth is a worldwide phenomenon responsible for significant changes in the population pyramid. In this context, the increase in life expectancy has contributed significantly to the growth of the elderly population. Considering that this age group is associated with a decline in the functional reserve of multiple organic systems, a condition capable of causing dysfunctions and diseases in the elderly, the best clarification about the implications of aging becomes essential. The present research
aimed to study the prevalence of anemia in a sample of elderly people in northeastern Brazil. To that, 90 elderly residents in Mossoró-RN, belonging to groups of elderly people assisted by Family Health Strategy teams and arranged in different Family Health Care Centers, completed a questionnaire with socioeconomic data and a biochemical test that evaluated serum hemoglobin (Hb) concentrations. The study found a prevalence of 12.2% of anemia in participants (Hb <12 g / dl in women and Hb <13 g / dl in men), which was was in agreement with other Brazilian studies that involved elderly enrolled in the Family Health Unit. However, a lower prevalence of the disease was observed when compared to studies that evaluated elderly people living in long-term institutions. In addition, it was found that 7.8% were illiterate; 47.2% had incomplete 1st grade; 16.7% had completed 1st grade; 16.7% had incomplete secondary education; 13.3% were in the 2nd grade; and 3.3% had 3rd grade. Besides that, attention to anemia in the elderly would help to improve the quality of senile life while reduces their impact on the global burden of diseases, explained in part by its correlation with poor nutritional status and major cognitive impairments, which are capable of interfering with daily activities and interaction of patients.

Keywords: Anaemia. Aged. Prevalence.

Authors:

Micheline M. F. C. Souza
Letícia L. Mendonça
José Edvan Souza-Júnior
Thiago L.H. Rego
José Rodolfo L.P. Cavalcanti

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