Author page: JPCBS

Bioactive and Nutraceutical Properties of Mushrooms in Body Aesthetic

Abstract:

Mushrooms are fruiting bodies of fungi, some species of edible mushrooms being used as part of traditional diets, such as a Mediterranean. In this sense, edible mushrooms have emerged as a viable alternative increasingly common in the Brazilian table due to their nutritional properties. This article aimed to evaluate the benefits of the bioactive and nutritional properties of mushrooms on body aesthetics. This study consists of a literature review where an electronic search was performed in the United States: PubMed, Science Direct, Cochrane Library, Scientific Electronic Library, Online Databases (SciELO), Scopus, Web of Science, Medline via Proquest and Capes Periodicals covering the years 1989-2019, using the terms “Nutrient Mushrooms” “Mushrooms, Vitamins, Food Supplementation” “Mushrooms and Nutrition and Micronutrients” “Mushrooms and Nutrition and Macronutrients”“Nutrient Mushrooms and Nutraceuticals “Mushroom and aesthetics” Mushroom and antioxidant. Mushrooms are rich in proteins with good bioavailability, low lipid content and excellent fiber source that can be used as nutritional, advanced for their bioactive compounds, polyphenols and other biological compounds that perform body aesthetic activities.

Keywords: Mushrooms. Macronutrients. Micronutrients. Body Aesthetics.

Authors:
Vinicius Umbelino de Freitas;
Anna Ingrid Soares de Sousa Espindola;
Catarina Melissa Carlos de Castro;
Fernando Liberalino Fernandes ;
Ninodja Kadja Peixoto Nóbrega;
Jenifer Kristina Alves Almeida;
Fausto Pierdoná Guzen.

Benefits of Supplementation with Herbal Medicines in Anabolic Hormone Replacement Related to Aging

Abstract:

Exercise can be carried out according to the morphological and physiological changes of the living organism over time. The increase in life expectancy is also an achievement along with functional decline and increased disease are observed. Aging in a healthy way for a general well-being, however, when aging is not successful, the elderly have a great tendency towards a functional, cognitive and other diseases, generating the total dependence of basic activities, thus determining the need care. The present article had the objective of supplementation with phytotherapics in the anabolic hormone replacement related to aging. The study was based on the literature review, and a case study was done in the United States. Library of Medicine, Pub Direct, Science Direct, Cochrane Library, Electronic Scientific Library, Online Databases (SciELO), Scopus, Web of Science, Medline via Proquest and Periodics capturing the years between 2007 and 2019, using the terms of reference “Aging and Metabolic Alterations” “Aging and Phytotherapics” “Aging and Tribulus terrestris” “Aging and Maca Peruvian” “Aging and Ginseng”, in addition we related the term hormone with each phytotherapeutic mentioned. They observe that the herbal remedies Tribulus terrestris, Maca peruana and Ginseng possess in their combination with the chemistry, anabolic, being thus, a supplementation with these products can allow an anabolic hormonal balance, generating the effect in the levels of catabolic hormones, providing a better This topic was extracted from population longevity.

Keywords: Aging. Anabolic Hormones. Herbal Medicine. Supplementation

Authors:
Anna Ingrid Soares de Sousa Espindola;
Bruna Stefany Souza Sabino;
Catarina Melissa Carlos de Castro Duarte;
Gabrielle Tereza Santos de Souza;
Marina Geovanni Marques de Santana;
Ninodja Kadja Peixoto Nóbrega;
Pedro Henrique Bezerra Gomes;
Ana Katarina Dias de Oliveira;
Fausto Pierdoná Guzen.

Serum Concentration on Mineral Zinc and Cognitive Changes in Children: a Review

Abstract:

Introduction: Micronutrient deficiencies in children in developing countries remain a public health problem, as they are persistently common. Among them, zinc is an essential trace element and plays a crucial role in biological functions and physiological processes in humans. Disorders of zinc balance during life appear to be an important factor correlated with the development of CNS diseases. This research aimed to conduct a literature review on the proportion of research involving zinc and brain development in children. Methods: A search was performed in the Pubmed, Scorpus, and Web of Science databases, and articles from the last 5 years were retrieved. According to the criteria, 7 articles were chosen to compose this review. Results: 57% revealed that children with ASD have low serum zinc levels, and 29% of the studies found lower plasma zinc levels in children diagnosed with ADHD. Revealing that attention to the levels of zinc in the plasma must be special, since mainly the levels of micronutrients, are decisive for a good biological, physiological, neurobiological, and behavioral development, acting on the personality and formation of the human being. Conclusion: In this perspective, we emphasize the importance of giving greater attention to the serum levels of adequate zinc in the human body, renewing the knowledge that adequate nutrition is of great importance for normal development from pregnancy to aging.

Keywords: Child. Zinc. Brain.

Authors:
Samillys Valeska Bezerra de França Silva;
Micheline Morgane Figueiredo Costa Souza;
Jéssica Raque de Santana;
José Edvan de Souza Júnior;
José Rodolfo Lopes de Paiva Cavalcanti.

Neurobiology of Schizophrenia: an Integrative Review

Abstract:

Psychological diseases are gaining more and more space in the medical field, being considered by some studious the evil of the century, as more and more people are affected worldwide. Among these diseases we have schizophrenia, which consists of a mental condition that modifies the perception of reality of the individual, impairing his memory and development of basic activities that require concentration and memorization. Because it develops mainly between adolescence and adulthood, without a defined cause, many studies and tests have been conducted for decades in order to o find out the precise causes of such disorders, since only with an accurate diagnosis can effective treatment be determined. From this perspective, this article aims to conduct a survey and discussion of the theoretical material already existing regarding the neurobiology of a schizophrenic in order to understand its mental disorders. Although research indicates which region of the brain, when affected, can cause disturbances there is no accuracy as to how the process occurs, it was also possible to notice little evolution in studies, and lack of accuracy of the causes of the changes neurobiologics which result in disorders.

Keywords: Psychic diseases. Neurobiology. Mental disorders.

Authors:
Ricardo dos Santos Cirilo;
Isabeline Maria de Góis Mendes Oliveira;
Fausto Pierdoná Guzen.

Clinical Applications of Nitric Oxide: Comprehensive Review

Abstract:

Around the year of 1986 nitric oxide was no longer seen by health professionals as a highly toxic molecule and began to be considered in clinical treatments. However, the discovery of their positive functions does not mitigate their negative characteristics, because of this, research and tests are performed on the functionalities and risks, however doubts and fears are still common. In biological organisms, nitric oxide may react with molecules and attenuate various processes, whereas when in contact with a high amount of the oxide or a been exposed for too long may cause intoxication. Therefore, further research and testing with the use of oxide are required to avoid com plications. Hence, the objective of the present research is to present the clinical complications caused by the use of nitric oxide in various treatments.

Keywords: Nitric Oxide. Clinical Application.

Authors:
Isabeline Maria de Góis Mendes Oliveira;
Ricardo dos Santos Cirilo;
Fausto Pierdoná Guzen.

Prevalence of anaemia in a sample of elderly northeastern brazilians

Abstract:
Population growth is a worldwide phenomenon responsible for significant changes in the population pyramid. In this context, the increase in life expectancy has contributed significantly to the growth of the elderly population. Considering that this age group is associated with a decline in the functional reserve of multiple organic systems, a condition capable of causing dysfunctions and diseases in the elderly, the best clarification about the implications of aging becomes essential. The present research
aimed to study the prevalence of anemia in a sample of elderly people in northeastern Brazil. To that, 90 elderly residents in Mossoró-RN, belonging to groups of elderly people assisted by Family Health Strategy teams and arranged in different Family Health Care Centers, completed a questionnaire with socioeconomic data and a biochemical test that evaluated serum hemoglobin (Hb) concentrations. The study found a prevalence of 12.2% of anemia in participants (Hb <12 g / dl in women and Hb <13 g / dl in men), which was was in agreement with other Brazilian studies that involved elderly enrolled in the Family Health Unit. However, a lower prevalence of the disease was observed when compared to studies that evaluated elderly people living in long-term institutions. In addition, it was found that 7.8% were illiterate; 47.2% had incomplete 1st grade; 16.7% had completed 1st grade; 16.7% had incomplete secondary education; 13.3% were in the 2nd grade; and 3.3% had 3rd grade. Besides that, attention to anemia in the elderly would help to improve the quality of senile life while reduces their impact on the global burden of diseases, explained in part by its correlation with poor nutritional status and major cognitive impairments, which are capable of interfering with daily activities and interaction of patients.

Keywords: Anaemia. Aged. Prevalence.

Authors:

Micheline M. F. C. Souza
Letícia L. Mendonça
José Edvan Souza-Júnior
Thiago L.H. Rego
José Rodolfo L.P. Cavalcanti

Evaluation of the hepatic funciotn of adult men under the use of testosterone base transdermal in the municipality of Belo Horizonte – MG / Brazil

Abstract:
Introduction: Recently, an expressive interest has developed about the importance of the condition known as male climacteric or andropause. In men this process is not universal, occurring in a portion of the male population with clinical manifestations that are more gradual than those occurring in menopausal women. Objective: The present study aimed to evaluate the hepatic function of adult men under testosterone transdermal use in the city of Belo Horizonte – MG / Brazil. Methods: The subjects of the research were men, patients of the Penchel Clinic admitted in 2017. As inclusion criteria, men would need to be between 19 and 55 years of age and total testosterone measured at values below 320ng / dl, which would characterize hormone insufficiency. After 60 days of hormone use, the men underwent biochemical reassessment for analysis of testosterone values. Results: Because it is a rapid absorption, short half life and non-return liver, this route of replacement becomes an excellent alternative of choice for testosterone in 100% of the subjects (p = 0.0441), suggesting that there was no statistically significant difference between the two measures evaluate GGT, the main acute marker of hepatic lesion alteration. Conclusion: Care for testosterone-deficient patients should focus on accurate assessment of total testosterone levels, symptoms and signs, as well as appropriate monitoring during treatment to ensure that therapeutic levels of testosterone are achieved and symptoms are improved.

Keywords: Transdermal hormone replacement; Testosterone; Liver function; Andropause.

Authors:
Lucas Mendes Penchel;
Amália Cinthia Meneses do Rêgo;
Irami Araújo-Filho;
Fausto Pierdoná Guzen;
Dinalva Brito de Queiroz.

Analysis of the influence of inoculation of ischiatic nerve fragments in the presence of astragalosíde ivin the neuroprotection of dorsal root ganglions in animals submitted to the transcription of the spinal cord

Abstract:
Introduction: Injury to the cord spinal is a complex medical disease, associated with a serious and disabling incapacity in life, predisposing to a systemic dysfunction that must lead to a secondary process, with a high risk of death. Objective: The objective of this study was to analyze the effects of sciatic nerve fragmentation in the presence of Astragaloside IV (AS-IV) on the neuroprotection of dorsal root ganglia after the transected spinal cord of the rat. Methods: The animals were submitted to a 4 mm long medullary transection at the lower thoracic level, and
sciatic nerve fragments plus 10 μl of saline solution (5%) were inoculated in the animals of group 1 and group 2, and fragments of sciatic nerves added 10μl of AS-IV. After 3 months the dorsal root ganglia parallel to the spinal cord region were removed and processed for tissue analysis using hematoxylin/ eosin staining. Results: In the group treated with sciatic nerve graft AS-IV, we observed the greatest preservation of the morphological root of the dorsal root ganglia when present in the group lacking AS-IV. Conclusion: Sciatic nerve grafting with the addition of AS-IV in the mouse transected marrow promotes neuroprotection in the dorsal root ganglion neurons.

Keywords: Sciatic Nerve; Astragalus Membranaceus; Spinal Cord; Dorsal Root Ganglion; Neuroprotection.

Authors:
Eurico de Souza Costa;
Dinalva Brito de Queiroz;
Amália Cinthia Meneses do Rêgo;
Francisco Irochima Pinheiro;
Irami Araújo – Filho;
Francisco Vitor Aires Nunes and
Fausto Pierdoná Guzen

Behavioral changes to frontotemporal dementia diagnosis

Abstract:
Introduction: Frontotemporal dementia (FTD) was first described in 1892 and consists of a frontotemporal atrophy that preserves the posterior lobes. Genetically, several changes have been associated with the disease. Its clinical manifestation occurs through three presentations, such as: behavioral variant, non-fluent variants andsemantics. The diagnosis relies on magnetic resonance imaging to rule out other diseases. Treatment is through the use of Serotonin Reuptake Inhibitors (SSRIs) to improve behavioral symptoms, including aggression, disinhibition and agitation. Methods: This is a systematic review of behavioral changes for the diagnosis of FTD. The PUBMED database was used for the research using the following keywords: “FTD”, “behavioral variant of FTD” and “diagnosis of frontotemporal dementia”. Results: Clinical manifestations correlate with the affected brain region. FTD patients may have apathy, which is one of the most common and disabling. It can also cause changes in sexual behavior. It is associated with a family history of neurodegeneration. Its most common form has a prognosis of survival of about 6 years. Discussion: There is a significant heterogeneity in psychiatric and neurological diseases, including neurodegenerative diseases, of which the most prevalent diagnosis was vcDFT, but there is a great shortage of studies on the subject. Tests such as the Mini Mental State Examination (MMSE) and the Frontal Assessment Battery (FAB) are among the most commonly used short screening instruments to assess these changes and differentiate syndromes. The diagnostic criteria aim to categorize patients regarding vcDFT as ‘possible’, ‘’ likely ‘’ and ‘’ defined ‘’. Effective, careful and appropriate medical evaluation is necessary to understand aspects of family history of neurodegenerative disorders. In addition, physical examination and cognitive assessment have the ability to identify most cases with likelihood of progression and can guide healthcare professionals to properly identify specific cases of FTD and refer patients to specific services if important. Conclusion: Therefore, due to their similarity with other dementia syndromes, it is necessary to create more specific instruments for their differentiation. It is also important to note that when the ability to perform executive activities is assessed, it is observed that there is impairment, whether in patients with progressing or controlled disease, which may be important in identifying and differentiating other dementia syndromes.

Keywords: Frontotemporal Dementia; Behavioral Change; Diagnostic; Treatment.

Authors:
Dallianny Gonçalves de Sousa Martins;
Tauê Posada Pereira;
Inavan Emerson da Costa Dantas;
Bárbara Mayã Austregésilo de Alencar;
Marconi Edson Maia Júnior;
Paula Cristina de Melo Santos and
Fausto Pierdoná Guzen

A short communication about vascular dementia

Abstract:
Introduction: The Vascular Dementia (VaD) is an irreversible neurocognitive disorder related to cerebrovascular disorders. It is considered the second most common type of dementia after Alzheimer’s disease. Methods: The references included reviews published in the last 5 years, found through a search on PubMed database using the terms “Vascular Dementia”, “Clinical Diagnosis” and “Cerebrovascular Disease”. The articles were selected by analyzing the title and the abstract. Results: The initial search found 2556 results. 105 articles were selected when analyzed by time period, type of work (review) and MEDLINE filters. Those were the ones analyzed by tittle and by abstract, which left 9 articles considered useful for the proposal. Discussion: An insufficient amount of data about the physiopathology of the Vascular Cognitive Impairment (VCI) were found. The absence of epidemiological data about VaD makes it impossible to develop researches related to the quantitative contribution of the vascular disease for VCI. The presence of coexisting comorbities in patients with VaD is a possible presentation, which turns important the correct identification of other simultaneous dementia cases. Conclusion: The VaD is considered a cognitive disorder that incorporates behavioral symptoms and locomotor system abnormalities. The repercussion of vascular disease in cognition is already known, but recent studies and advances in neuropathology, genetic and epidemiology have helped to deeply understand the VaD and its relation with VCI.

Keywords: Vascular Dementia; Clinical Diagnosis; Cerebrovascular Disease.

Authors:
Alcivan Batista de Morais Filho;
Bárbara Mayã Austregésilo de Alencar;
Danilo Alvarenga Ferreira;
Marconi Edson Maia Júnior;
Renan Cavalcante Souza;
Tatiana Leal Marques and
Fausto Pierdoná Guzen

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