Author page: JPCBS

Priestly Performance and the Use of Medicines for Mental Health

The high stress felt by professionals from the most diverse fields has caused the excessive consump­tion of medications. The problem is aggravated because the use of these does not always happen through the proper guidance of a professional, and this occurs for many reasons. It is noteworthy that the choice for this search for cure of various di­sorders, including food, psychological or even al­coholic ones, happens due to the exaggerated fear of what people around them will understand about the comorbidities that the subject feels. Finally, it is clear that these individuals need to disassocia­te their improvement only from their connection with faith and the consumption of over-the-counter medications, both of which are important, but with due professional guidance, which until then was non-existent.

Keywords: Health assessment. Medicines.Mental health. Priests.

Ricardo dos Santos Cirilo;
Fausto Pierdoná Guzen.

Neuroprotective Effect Promoted by Bitartrate

 The hippocampus is considered a central brain structure in memory formation mechanisms. With regard to Choline Bitartrate, it can be said that it is a substance capable of helping to improve an individual’s memory. Chronic choline intake has been suggested to improve behavioral, oxidative, and neurochemical outcomes in the normal popu­lation, as a safe and effective supplement to impro­ve neurological health in normal individuals, and that they may also be beneficial in preventing more phased cognitive and motor disorders late in life. In addition to observing behavioral changes after choline administration, the effect of chronic cho­line administration on changes in the redox state of the brain and on neurochemical changes in the brain and hippocampus was also determined.

Keywords: Hippocampus. Bitartrate. Neuroprotection.

Mariana Mendes Pinto;
Fausto Pierdoná Guzen.

Phytol, a Chlorophyll Component, Prevents Motor Impairments Induced by Reserpine in Rats

 Phytol (PHY), a constituent of chlorophyll, has some pharmacological properties such as an­tioxidant, anti-inflammatory, anxiolytic, antide­pressant, and antihyperalgesic effects. Compou­nds like this one have a high potential to develop neuroprotective action. Repeated administration of reserpine (RES) in rodents induces motor im­pairments and has been applied has been applied to Parkinson’s disease (PD) and tardive dyskinesia (TD) animal models. Therefore, the present study investigated whether phytol administra­tion would attenuate reserpine-induced motor impairments in rats. Male Wistar rats received subcutaneous injections of 1 mg/kg RES or vehicle, in two conse­cutive days, concomitantly with intra­peritoneal injections of PHY (50 mg/ kg) or vehicle. Catalepsy test was asses­sed from day 1 to day 3. On day 3, oral movements and locomotor activity were evaluated. Our results showed that PHY prevented an increase in cataleptic beha­vior, number of vacuous chewing move­ments, oral tremor, and tong protrusion. However, it was unable to prevent a re­duction in open-field locomotor activity induced by RES. Our results suggest that PHY shows a protective effect in in PD and TD animal models, preventing mo­tor impairments induced by RES.

Keywords: Neuroprotective Effect. Diterpenes. Parkinson Disease. Tardive Oral Dyskinesia.

Wesley Santos Santana;
Edson de Rezende Santos;
Heitor Santos Franco;
Mylaine Santos Mendonça;
Thiago Henrique Almeida-Souza;
Ana Cleia A. da Luz;
José Leandro Santos Souza;
Auderlan Mendonça de Gois;
Pollyana Caldeira Leal;
Lucindo José Quintans-Júnios;
José Ronaldo dos Santos.

Mental Health of Priests

Psychological illnesses are becoming one of the biggest problems in the world, as they affect a lar­ge number of people, regardless of age, ethnicity or class, in addition to being difficult to identify and treat. Studies show that adopting an active spi­ritual life can be effective in treating illnesses or aggravations, starting to seek a meaning for their existence and comfort for their pain. Depression is a subject that has been increasingly discussed in the media, social networks and academic envi­ronments, it is characterized by a set of depressive symptoms that when they appear for a long time cause a functional impairment for the individual, can be diagnosed as a disease, that is, it is not a sporadic sadness. Depression is a change in mood, and within health, mood is not described as joy or sadness, considering that these characteristics have very superficial aspects to define such a com­prehensive theme.

Keywords:  Mental health. Priests. Church.

Isabeline Maria de Góis Mendes de Oliveira;
Fausto Pierdoná Guzen.

Brain Skills® promotes neuronal migration and development in cultivated human brain tissue

The evolution of large human brain size has had important implications for the nutritional biology of our species. The question of whether brain func­tion is entirely genetically determined or may be influenced by the environment or by nutrition has been debated for decades. Large brains are energe­tically expensive, and humans expend a larger pro­portion of their energy budget on brain metabolism than other primates. Military interest in the effects of nutritional factors on brain function has stimula­ted considerable research on a variety of food cons­tituents. In this perspective, Brain Skills®, which consists of an association of amino acids, vitamins, minerals, precursors of neurotransmitters and an­tioxidants, was tested in human neuron cultures. Brain Skills® promoted greater migratory and neu­roplastic effects after 72 hours of treatment.

Keywords: Brain Skills. Culture. Plasticity. Neuron Development.

Fausto Pierdoná Guzen

Neuroplastic effect induced by Brain Skills®️ was observed in human brain cell culture

Cognitive function plays an important role in brain performance and it seems that brain functioning can be influenced by nutrition and dietary com­ponents. Nutrients regulate brain development during life, being essential for migration, growth, synapse, myelination and antioxidant/neuropro­tective effect. Conversely, the young brain is re­markably plastic and therefore more amenable to repair after nutrient repletion. In this perspective, Brain Skills ®, which consists of an association of amino acids, vitamins, minerals, precursors of neurotransmitters, energy generators and an­tioxidants, was tested in human neuron cultures. Cultured human brain tissue was maintained in culture medium in the presence or absence of ®. Brain Skills ® promoted a neuroplastic effect af­ter 72 hours of treatment, showing more develo­ped neurons, larger cell bodies, greater dendritic and axonal plasticity, in addition to presenting a greater amount of synaptic contact. The results demonstrated that the product Brain Skills ® had a significant effect on the neuroplastic development of human neurons.

Keywords: Brain Skills. Brain Culture. Development. Neuroprotection. Neuroplasticity

Fausto Pierdoná Guzen

Anti Obesity Action of Omega-3 Supplementation in Wistar Rats

Obesity and Its co morbidity has become a world endemic health problem. Among several triggers to this condition, evolution in diet composition with large amounts intake of energetic foods, ad­ded to limited physical activities due to the mo­dern people habits, are notables factors. Change in ratio omega-6/omega-3 fatty acids intake is an important obesity cause and can make the co mor­bidity become worst. A large number of researches evidences the role of the fatty acids omega-6/ôme­ga3 ratio as effective health promoter by, modu­lating its bio-active derivatives; the eicosanoids and cytokines. The aim of this study is to evidence the anti obesity effect of a diet supplementation with omega-3 fatty acids, and, specific aims are following up rats corporal weight, adipocytes size and blood levels of total cholesterol, high densi­ty lipoprotein (HDL) and triglycerides. This was an experimental study with five Wistar male rats groups (n=6), with body weight upper 260g. One group was euthanized at day one; two groups re­ceived intake of water by gavage during 45 and 90 days, respectively, and two groups received intake of 0,1mg/kg/weigh/day of high purified omega-3 (EPA 350 mg/ml + DHA 220 mg/ml) for 45 and 90 days. All animals received intake of water and food at libitum du­ring the experience.The results showed decreasing in blood total cholesterol, and triglycerides levels (p<0,05), increase in HDL blood level (p<0,05), decrease in weight and had reduced its adipocytes area (p< 0,01) with omega-3 intake. The group which received omega-3 during 45 days compared to the 90 days group choose less parameter reductions. None of the rats presented any sign of side ef­fects during the study. Conclusion: the current study evidenced ante obesity ef­fect, in rats, of omega-3 fatty acid intake. This effect was time-dependent.

Keywords:  PUFAS n-3. Obesity. Metabolic Syndrome. Low grade Inflammation.

Silvana Macedo de Araújo;
Ramon da Silva Raposo;
Renato de Azevedo Moreira;
Dinalva Brito de Queiroz;
Fausto Pierdoná Guzen.

Trophic Performance of Neurons of the Prefrontal Cortex of Newborn Wistar Rats in Culture After Addition of Phosphatidylserine

Introduction: The surface of the cortex is formed by bodies of neural cells that process all the infor­mation that the brain receives and sends, enabling man to think, plan, coordinate thoughts and ac­tions, perceive visual and sound patterns and use languages. The prefrontal cortex (CPF) is a com­plex and highly developed region of the neocorti­cal regions of the human brain, being considered the frontal cortex association cortex. Objective: To analyze the effects of supplementation with different dosages of Phosphatidylserine on the neuroprotection and plasticity of nerve cells in the prefrontal cortex of cultured newborn Wister rats. Methods: the experimental procedures were con­ducted under license from the Ethics Committee on Animal Experimentation (CEEA) of the State University of Rio Grande do Norte (UERN), with opinion number 015/2016. The cellular material of the cerebral cortex was collected from 2 newborn Wistar rats, 2 days old. Then cultivated in diffe­rent groups, one control (D10 = G1) and the others, containing different concentrations of phosphatidylserine, PS (G2 = 1 μg, G3 = 2 μg and G4 = 3 μg). Scanning electron microscopy (SEM) was used to evalua­te growth and cell morphology after 72 hours. To verify normality, the Kolmo­gorov-Smirnov and Shapiro-Wilk tests were used and to confirm the results, two post-tests were performed – Tukey and Bonferroni – with the difference results with p <0.05 being considered statisti­cally significant. Results: We evidenced that the group G4 treated with 3 μg of the phosphatidylserine conditioned me­dium, presented significant morphologi­cal growth when compared to the groups G1 = D10, G2 = 1 μg and G3 = 2 μg, su­ggesting that this phosphate may act pro­moting neuroprotection and plasticity to neurons of the cerebral cortex, in culture. Conclusion: The neuroprotective effect and the preservation of neuroplasticity of cells in culture are notorious. By the way, phosphatidylserine promoted the maintenance of cell expansion in the ex­perimental groups, mainly in the group treated with conditioned medium of 3μg, allowing the more expressive identifica­tion of the cell morphology, indicating its action in the neuroprotection of the cerebral cortex cells.

Keywords:  Pre-frontal córtex. Phosphatidylserine. Neuroprotection. Cerebral Plasticity.

Rosângela Symara Lima Araújo;
Amália Cinthia Meneses do Rêgo;
Fausto Pierdoná Guzen.

Dietotherapy in Health Promotion and Recovery in Seropositive Patients

Introduction: Nutritional guidance Works as a gradual process of diet adhering, whereby human immunodeficiency virus patients are advised to take responsibility and become aware of the food relationship in the treatment itself. Thus, it is possible to promote a better quality of life for these patients. Objectives: Address the need for nutritional care and follow-up of seropositive human immunodeficiency patients. Methods: Consists of a literature review, where an electronic research was carried out in the databases: PubMed, SciELO, LILACS, Capes Journal Portal, as well as printed literature, covering the years between 1995 and 2020. Results: Nutritional assessment of seropositive patients should be comprehensive and judicious, including the detection of symptoms associated with viral infection and anthropometric and biological parameters. From this, nutritional risks are identified and associated with gastrointestinal, autoimune and opportunistic pathologies. It is essential that HIV-patients receive nutritional therapy early and continuously, aiming at food reeducation and adequate supply of macros and micronutrients. Conclusion: Since there is no pre-established definitive nutritional assessment or therapy for HIV-patients, the main purpose of treatment is the recovery of nutritional status as well as its immunological status, thus promoting necessary conditions for body homeostasis and disease remission.

Keywords: Nutritional Assessment; Supplementation; Immunodeficiency.

Marcos Vinícius Luz de Oliveira;
Natália Chagas de Oliveira;
Francisco Sérvulo de Oliveira Carvalho;
Lara Barbosa de Souza.

Physiological and Clinical Aspects of Eletrical Synapse: Emphasis of the Connexin 36

The aim of this review is to gather recente findings from the literature on how electrical synapses act and how changes in their structure, with emphasis on conexin 36 influences clinical aspects. Research studies have been selected based on research topics found in globally recognized databases such as Web of Science, PubMed, Springer and Scopus from 2009 to date and ranked by relevance. Previously, it was believed that brain functioning required only electrical circuits for decision making. However, John Eccles has proven the predominance of chemical synapses in the nervous system; This hypothesis that led to discrediting the functionality of electrical synapses. However, several studies have described the structure of the gap junctions and the mechanisms of the electrical synapse, which occurs through two mechanisms: through low resistance interneuronal pathways through the communicating junctions and through extracellular electric fields generated by nerve cell activity. Therefore, it is a fact that this form of cellular communication has greater clinical applicability such as synchronization of electrical transmission in different neural groups. The prime example of this applicability is the existence of mixed synapses. This feature may be the key point for clarifying the genesis of various pathologies associated with cognitive disorders, learning and memory deficits.

Keywords: Electrical Synapses; Connexin36; Neuronal Gap Junctions.

Hosana Mirelle Goes e Silva Costa;
Paulo Leonardo Araújo de Góis Morais;
Débora Lopes Silva de Souza;
Claudio Lopes de Vasconcelos;
Dayane Pessoa de Araújo;
Lucidio Clebeson de Oliveira;
José Edvan de Souza Júnior;
Fausto Pierdoná Guzen;
José Rodolfo Lopes de Paiva Cavalcanti.

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