Anti Obesity Action of Omega-3 Supplementation in Wistar Rats

Obesity and Its co morbidity has become a world endemic health problem. Among several triggers to this condition, evolution in diet composition with large amounts intake of energetic foods, ad­ded to limited physical activities due to the mo­dern people habits, are notables factors. Change in ratio omega-6/omega-3 fatty acids intake is an important obesity cause and can make the co mor­bidity become worst. A large number of researches evidences the role of the fatty acids omega-6/ôme­ga3 ratio as effective health promoter by, modu­lating its bio-active derivatives; the eicosanoids and cytokines. The aim of this study is to evidence the anti obesity effect of a diet supplementation with omega-3 fatty acids, and, specific aims are following up rats corporal weight, adipocytes size and blood levels of total cholesterol, high densi­ty lipoprotein (HDL) and triglycerides. This was an experimental study with five Wistar male rats groups (n=6), with body weight upper 260g. One group was euthanized at day one; two groups re­ceived intake of water by gavage during 45 and 90 days, respectively, and two groups received intake of 0,1mg/kg/weigh/day of high purified omega-3 (EPA 350 mg/ml + DHA 220 mg/ml) for 45 and 90 days. All animals received intake of water and food at libitum du­ring the experience.The results showed decreasing in blood total cholesterol, and triglycerides levels (p<0,05), increase in HDL blood level (p<0,05), decrease in weight and had reduced its adipocytes area (p< 0,01) with omega-3 intake. The group which received omega-3 during 45 days compared to the 90 days group choose less parameter reductions. None of the rats presented any sign of side ef­fects during the study. Conclusion: the current study evidenced ante obesity ef­fect, in rats, of omega-3 fatty acid intake. This effect was time-dependent.

Keywords:  PUFAS n-3. Obesity. Metabolic Syndrome. Low grade Inflammation.

Silvana Macedo de Araújo;
Ramon da Silva Raposo;
Renato de Azevedo Moreira;
Dinalva Brito de Queiroz;
Fausto Pierdoná Guzen.

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