Analysis of the influence of inoculation of ischiatic nerve fragments in the presence of astragalosíde ivin the neuroprotection of dorsal root ganglions in animals submitted to the transcription of the spinal cord

Introduction: Injury to the cord spinal is a complex medical disease, associated with a serious and disabling incapacity in life, predisposing to a systemic dysfunction that must lead to a secondary process, with a high risk of death. Objective: The objective of this study was to analyze the effects of sciatic nerve fragmentation in the presence of Astragaloside IV (AS-IV) on the neuroprotection of dorsal root ganglia after the transected spinal cord of the rat. Methods: The animals were submitted to a 4 mm long medullary transection at the lower thoracic level, and
sciatic nerve fragments plus 10 μl of saline solution (5%) were inoculated in the animals of group 1 and group 2, and fragments of sciatic nerves added 10μl of AS-IV. After 3 months the dorsal root ganglia parallel to the spinal cord region were removed and processed for tissue analysis using hematoxylin/ eosin staining. Results: In the group treated with sciatic nerve graft AS-IV, we observed the greatest preservation of the morphological root of the dorsal root ganglia when present in the group lacking AS-IV. Conclusion: Sciatic nerve grafting with the addition of AS-IV in the mouse transected marrow promotes neuroprotection in the dorsal root ganglion neurons.

Keywords: Sciatic Nerve; Astragalus Membranaceus; Spinal Cord; Dorsal Root Ganglion; Neuroprotection.

Eurico de Souza Costa;
Dinalva Brito de Queiroz;
Amália Cinthia Meneses do Rêgo;
Francisco Irochima Pinheiro;
Irami Araújo – Filho;
Francisco Vitor Aires Nunes and
Fausto Pierdoná Guzen

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