Introduction: Injury to the cord spinal is a complex medical disease, associated with a serious and disabling incapacity in life, predisposing to a systemic dysfunction that must lead to a secondary process, with a high risk of death. Objective: The objective of this study was to analyze the effects of sciatic nerve fragmentation in the presence of Astragaloside IV (AS-IV) on the neuroprotection of dorsal root ganglia after the transected spinal cord of the rat. Methods: The animals were submitted to a 4 mm long medullary transection at the lower thoracic level, and
sciatic nerve fragments plus 10 μl of saline solution (5%) were inoculated in the animals of group 1 and group 2, and fragments of sciatic nerves added 10μl of AS-IV. After 3 months the dorsal root ganglia parallel to the spinal cord region were removed and processed for tissue analysis using hematoxylin/ eosin staining. Results: In the group treated with sciatic nerve graft AS-IV, we observed the greatest preservation of the morphological root of the dorsal root ganglia when present in the group lacking AS-IV. Conclusion: Sciatic nerve grafting with the addition of AS-IV in the mouse transected marrow promotes neuroprotection in the dorsal root ganglion neurons.
Keywords: Sciatic Nerve; Astragalus Membranaceus; Spinal Cord; Dorsal Root Ganglion; Neuroprotection.
Eurico de Souza Costa;
Dinalva Brito de Queiroz;
Amália Cinthia Meneses do Rêgo;
Francisco Irochima Pinheiro;
Irami Araújo – Filho;
Francisco Vitor Aires Nunes and
Fausto Pierdoná Guzen